A good PET scan requires an
ideal tracer injection.
Quality Assurance and Quality Control for your imaging procedures.
The quality of a clinical PET/CT scan relies on delivering a precise dose of radiotracer to the patient for a precise uptake period.
Precise dose information is necessary to accurately calculate results based on the PET image. Standard practice is to measure the empty syringe in the well counter, so that any remaining radioactivity can be netted from the original syringe value, to establish an accurate net injected dose.
Consistency of uptake period length is required to ensure sufficient contrast in the scan for evaluation, as well as comparability of the resulting image to other images. Bolus injections (a volume of fluid injected rapidly) are standard practice to deliver the radiotracer to the patient’s circulation all at the same time to start the uptake period.
Sometimes a paravenous injection of the radiotracer occurs. When the radiotracer is injected or leaks into the tissue surrounding the injection site, it is known as an infiltration, sometimes referred as an extravasation.
Infiltrations cause PET calculations to be made with erroneous data and therefore can affect PET interpretation and patient management. Infiltrations impact both the dose available to the patient during uptake and the effective length of the uptake period–both key quality indicators. Radiotracer remaining near the injection site means that some portion of the dose is not circulating as required for the full uptake period.
By providing vital quality control information regarding the injection, the Lucerno system gives the clinicians what they need to determine if an infiltration has occurred and additional information to help characterize the severity. This knowledge helps determine the level of confidence the clinician can have when making patient management decisions based on a PET/CT image.
Result: better quality care and lower cost.
Infiltrations are surprisingly common.
Infiltrations are only visible if the injection site is in the PET field of view. Most injections are administered in the arm, wrist, or hand. In many PET studies, the patient’s arms are raised above their head, resulting in the injection site being outside the field of view for the PET image. A recent study indicates that approximately one third of all visible infiltrations may not be picked up by clinicians reading the scans due to the limits of the field of view.
Infiltrations are hard to quantify.
A static PET image cannot provide true insight into the extent of the infiltration. In an investigational study, Lucerno technology captured infiltrations that were significantly different in scale throughout the uptake process, but resulted in PET images that appeared relatively similar. It is not surprising that infiltrations can resolve at different rates. The Lucerno system provides information that does not exist today–real visibility as to the extent of the infiltration during the uptake process.
Was the injection successful?
Before the Lucerno’s technology was available, there was no good way to tell if a bolus injection was successful. One limitation is that not all injection sites are imaged. Another limitation is that the PET image is a static snapshot, and cannot show the clinician what happened during the uptake period that could affect the quality of the image. As a result, clinicians may be making patient management decisions with a compromised diagnostic: they may be unaware that an infiltration has impacted the PET image, or if they see and infiltration, they may underestimate the degree of infiltration.
This is not a trivial issue. While there is not much public information available on infiltration rates, three large centers have published journal articles indicating their infiltration rate to be between 10% and 20%. Automated injectors may reduce the rate, but not to zero. At these rates, approximately 700,000 patients each year are affected worldwide. Lucerno studies confirm the published rates.
Lucerno can address this quality gap with a simple tool used in conjunction with the PET injection process. By providing insight into the success of the injection before moving the patient to the PET/CT scanner, Lucerno can provide clinicians with important quality information to improve outcomes. By combining the Lucerno dynamic data with the static PET image, the clinician can better characterize the severity of the infiltration before patient management decisions are made.
We conclude dose extravasations were commonly encountered (10.5%) in PET/CT. However, it is underreported by at least 31% due to omitting injection site from the FOV. When present, extravasations may lead to underestimation of SUVmax.
The quantitative evaluation of patient studies revealed that paravenous injection is a relatively frequent effect (18%) with a small fraction of patients presenting considerable extravasations ranging from 1% to a maximum of 22% of the injected dose.
The Lucerno Solution
The Lucerno Lara® System is currently listed with the FDA and uses surface sensors to measure the radiation emitted from the areas of interest beneath the sensors.
Prior to the injection, sensors are placed on each arm, so one captures the radioactivity from the radiotracer at the injection site and the other serves as a control. Forty-five minutes after the injection, the sensors can be removed and recorded data can be uploaded to Lucerno. Within seconds, Lucerno provides a report.
Since our sensors record the level of radiotracer in the areas of interest during and after the injection, Lucerno provides clinicians with evidence of the level of radiotracer in the injection area during the uptake process. This information allows clinicians to evaluate the quality of the injection process to determine if an infiltration has occurred, and therefore the level of confidence that can be placed in the PET image used in the patient management decision making.
The system is agnostic to the field of view in each clinic, the experience of the technologists, the quality of the patient’s injection vein, or if an auto-injector is used.
The system is easy to use, requires no additional radiotracer, and just adds one to two minutes to the process, but provides the quality control needed to ensure a PET scan has not been compromised by an infiltration.
Quality control of injections is important for everyday use of PET scans and vital for clinical studies that rely on PET scans as part of the protocol.
It is extremely important to control the quality of the PET/CT scan, particularly when it has implications for monitoring response to therapy and the management of the patient.
The Lucerno sensor can assess the quality of the injection process, removing at least one potential source of variability from the scan protocol.
This Lucerno graph shows the results of four scans taken over six months for the same patient. The green lines are from the bicep sensor on the left arm, the injection arm. The spike and immediate drop in the green lines during the first 20 seconds reflects the radiotracer bolus passing underneath the sensor during the actual injection. This initial spike, combined with the following stabilization at a low level of radioactivity–indicative of the expected low metabolic activity in this area of interest–suggests an ideal injection of the radiotracer.
The red line in the Lucerno graph (below left) shows a dramatically high level of radioactivity detected by the right arm sensor on the injection arm during the entire pre-PET uptake period. This high level of radioactivity resolves very minimally over the pre-PET uptake period. Tumor area of interest uptake (black line) was impacted by the fact that much of the radiotracer dose remains in the injection arm during the uptake period. The green line shows the readings from the left arm sensor, in this case, the control. When the Director of Nuclear Medicine and Positron Emission Tomography reviewed the resulting PET scan image (below right), she noted that there was “a lot of infiltration” and concurred with the Lucerno graph.
An infiltration, but how extensive?
The graph (below left) shows a patient scan with a small amount of radiation in the area of interest over the injection site. The red line drops sharply and nearly returns to a low, stable level of radioactivity, but still remains noticeably higher than the control. The Director of Nuclear Medicine and Positron Emission Tomography reviewed the PET image (below right) and classified this patient as having a “slight infiltration”. While the static PET image only captures a moment in time, we can confirm with the Lucerno graph that this patient had a slight infiltration during the uptake period.
The third example graph (below left) shows a patient scan with a significant level of radiation in their left arm (green line) that resolved very differently from the previous patient, yet resulted in a similar, static PET image (below right).
The PET images for both these patients indicate only a slight infiltration. Because the infiltrations resolved at different rates, there was no way to tell from the static PET image that the infiltration was dramatically more extensive for the third patient (below) compared to the second patient (above), and therefore would have a far greater affect on the quantification of the PET scan, potentially impacting a clinician’s patient management decision.
Lucerno can provide QA/QC for all PET radiotracer injections.
The Lara® System is intended for use in nuclear medicine to provide quality control for radiotracer injections. With the Lara® System, clinicians can know, before the uptake period is over, whether the injection was ideal or not.
While it is important to provide quality control for each individual radiotracer injection, the Lara® System can provide quality assurance for a nuclear medicine center’s injection process. By using the Lara® System with Lucerno’s proprietary software, centers can identify contributing factors, make appropriate adjustments, and improve quality. Through periodic reviews of contributing factors and process improvements, centers can drive their overall infiltration rate down, and drive their quality indices up.
Questions? We have answers.
What is an 18F-FDG (FDG) infiltration?
How does an infiltration happen?
While gaining access:
• A puncture through the posterior wall of the vein can occur.
• Arm movement, after catheter placement and prior to injection, can cause the catheter tip to damage the vein wall.
• Injecting the FDG dose too rapidly can increase intraluminal pressure enough to rupture the vein wall, sometimes referred to as “blowing a vein”.
• Thrombosis or restriction of the normal venous blood flow, proximal to the injection site, can adversely impede the flow of the radiotracer to the systemic circulation.
All of these problems are more common in patients with chronic illnesses that have required repeated venous access. Patients with cancer who have been treated with sclerosing chemotherapy regimens are particularly prone to issues with venous access and infiltrations.
Do infiltrations really matter to the results of a PET/CT scan?
How does an infiltration impact quantitative PET/CT results?
How does an infiltration impact qualitative PET/CT results?
Is it possible to assess infiltrations in PET/CT images and then correct the results?
Why aren’t injection sites in the field of view all the time? Is this a problem?
If a clinician can see the injection site, why is it difficult to quantify the infiltration?
Why would quantifying a visible infiltration be of limited value?
What if the infiltration is truly minor, does that matter to the dose and to the PET/CT results?
Are infiltrations tracked?
• The only way to track infiltrations today is to review PET/CT images for infiltrations. Nuclear medicine centers using a field of view from skull base to mid thighs will miss many infiltrations. Only centers that always image the injection site can realize that infiltrations have occurred.
• Reviewing past radiology reports is not an effective way to track infiltrations, since visible infiltrations (especially those considered to be minor infiltrations) are not always reported by clinicians.
• When injecting FDG, technologists are often unaware that an infiltration has occurred and therefore do not follow the self-reporting guidelines, which advise imaging the injection site. The physical volume of FDG that a technologist injects into a patient is usually small; therefore, a visible manifestation of an infiltration is often not evident to the patient or the technologist. Finally, FDG does not usually cause the patient much, if any, discomfort so technologists are not alerted to a possible concern.
In the hospitals that have looked into this issue by reviewing every image, what is the rate of infiltrations?
Aren’t most of the reported infiltrations minor?
What is the bottom line about the impact of FDG infiltrations?
Will infiltrations continue to be an important issue in the future?
How can we fix this FDG infiltration problem?
Will identifying FDG infiltrations lead to the complete elimination of infiltrations?
The Lara® system is FDA listed for the QA/QC application described on this page.